Activation conformation of propionic acid anti-inflammatory agents.
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منابع مشابه
Sinapic Acid Derivatives as Potential Anti-Inflammatory Agents: Synthesis and Biological Evaluation
Transcription factor NF-κB and relevant cytokines IL-6 and IL-8 play a pivotal role in thepathogenesis of inflammation. Sinapic acid is a natural product and was demonstrated to possessanti-inflammatory activity. In this paper, we synthesized a series of sinapic acid derivativesand evaluated their anti-inflammatory effects. The result suggested that all of the targetscompounds 7a-j inhibit NF-κ...
متن کاملSinapic Acid Derivatives as Potential Anti-Inflammatory Agents: Synthesis and Biological Evaluation
Transcription factor NF-κB and relevant cytokines IL-6 and IL-8 play a pivotal role in thepathogenesis of inflammation. Sinapic acid is a natural product and was demonstrated to possessanti-inflammatory activity. In this paper, we synthesized a series of sinapic acid derivativesand evaluated their anti-inflammatory effects. The result suggested that all of the targetscompounds 7a-j inhibit NF-κ...
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The pyrrole derivatives la, b and 2a, b were used as precursors for the preparation of N-substituted pyrrole derivatives 3a, b-9a, b and pyrrolo[2,3-d]pyrimidines 13-16. Also, all the newly prepared products were tested for anti-inflammatory activity as analogues to fenamates, and some of them revealed moderate anti-inflammatory activity compared to the standard drug indomethacin.
متن کاملNucleic acid-binding polymers as anti-inflammatory agents.
Dead and dying cells release nucleic acids. These extracellular RNAs and DNAs can be taken up by inflammatory cells and activate multiple nucleic acid-sensing toll-like receptors (TLR3, 7, 8, and 9). The inappropriate activation of these TLRs can engender a variety of inflammatory and autoimmune diseases. The redundancy of the TLR family encouraged us to seek materials that can neutralize the p...
متن کاملAnti-inflammatory and Analgesic Agents
Inflammatory diseases including arthritis and rheumatism are major group of prevalent diseases. Most of the available non-steroidal anti-inflammatory drugs are effective in inflammatory conditions of the joints, but are devoid of gastro protective property. Many substances, interfering with the inflammatory response have been isolated from Indian medicinal plants (IMP). The review analyses form...
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ژورنال
عنوان ژورنال: Nihon Kessho Gakkaishi
سال: 1990
ISSN: 0369-4585,1884-5576
DOI: 10.5940/jcrsj.32.86